Mechanism of Disease | gMG NEVER RESTS

SEE THE ROLE OF BOTH AChR & MuSK
AUTOANTIBODIES IN gMG

gMG is caused by pathogenic immunoglobulin G (IgG) autoantibodies that
target components of the neuromuscular junction (NMJ). The two main
types of autoantibodies target either acetylcholine receptors (AChR) or
muscle-specific kinase (MuSK).^17-20

UP TO 88%

AChR autoantibodies

ARE DETECTED IN PATIENTS WITH gMG^17-19

10-15%

MuSK
AUTOANTIBODIES

ARE DETECTED IN PATIENTS WITH gMG²⁰

EXPLORE HYPOTHETICAL AChR+ AND MuSK+ PATIENT PROFILES

VIDEO GUIDE

0:00 - :45 gMG overview, symptoms, and daily impact

0:46- :55 The prevalence of uncontrolled disease

0:56 - 1:12 Non-autoantibody specific MOD overview

1:13 - 1:46 The prevalence of AChR, MuSK and LRP4 autoantibodies in MG

1:47 - 2:20 AChR+ MOD: AChR autoantibody binding and resulting complement activation interrupt normal synaptic function

2:21 - 2:50 Complement: one of the main causes of NMJ destruction

2:51- 3:13 MuSK+ MOD: MuSK autoantibodies cause loss of acetylcholine receptors, resulting in muscle weakness

3:14 - 3:38 The role of endothelial cell recycling of antibodies

3:39 - 3:51 Long-term side effects of conventional treatments

3:52 - 4:05 A message from UCB

Learn how to identify uncontrolled gMG >

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