DISCOVER WHY
UNCONTROLLED gMG
NEVER RESTS

~50%

of patients

WITH gMG REMAIN UNCONTROLLED^1-4

In approximately half of patients with generalized myasthenia
gravis (gMG), the disease remains uncontrolled.

This means that they cope with moderate-to-severe symptoms,
along with the ongoing risk of exacerbations, that can disrupt
their lives and plans—despite being on treatment.^1-7

~50%of patients (N=1140)

HAD MODERATE-TO-SEVERE gMG, DEFINED AS HAVING A MYASTHENIA GRAVIS ACTIVITIES OF DAILY LIVING (MG-ADL) SCORE OF 6 OR ABOVE¹*

36%of patients (N=372)

REPORT THEIR TREATMENTS IMPACT THEIR ABILITY TO LEAD A NORMAL LIFE⁸

26%of patients (N=372)

REQUIRED IVIG WITHIN A 6-MONTH PERIOD DUE TO EXACERBATIONS OR INABILITY TO REDUCE MAINTENANCE THERAPY⁸

DISCOVER MORE ABOUT UNCONTROLLED gMG

WHAT CAUSES gMG?

Review the gMG mechanism of disease.

HOW CAN YOU IDENTIFY UNCONTROLLED gMG?

Explore the ongoing burden that patients
can experience.

IS gMG UNCONTROLLED IN THESE PATIENTS?

Meet 3 hypothetical patient case studies.

RESOURCES

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References

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Tran C, Biswas A, Mendoza M, Katzberg H, Bril V, Barnett C. Performance of different criteria for refractory myasthenia gravis. Eur J Neurol. 2021;28(4):1375-1384.
Petersson M, Feresiadou A, Jons D, et al. Patient-reported symptom severity in a nationwide myasthenia gravis cohort. Neurology. 2021;97:e1382-e1391.
Grob D, Brunner N, Namba T, Pagala M. Lifetime course of myasthenia gravis. Muscle Nerve. 2008;37(2):141-149.
Silva, P. MG patients satisfied with treatment, but quality of life could be better, US survey shows. Myasthenia Gravis News. June 17, 2021. Accessed April 14, 2022. https://myastheniagravisnews.com/news-posts/2021/06/17/mg-patients-want-better-quality-of-life-us- survey-shows/?cn-reloaded=1
Mendoza M, Tran C, Bril V, Katzberg HD, Barnett C. Patient-acceptable symptom states in myasthenia gravis. Neurology. 2020;95(12):e1617-e1628.
Xin H, Harris LA, Aban IB, Cutter G. Examining the impact of refractory myasthenia gravis on healthcare resource utilization in the United States: analysis of a Myasthenia Gravis Foundation of America patient registry sample. J Clin Neurol. 2019;15(3):376-385.
Data on file. Ra Pharma, 2018.
Juel VC, Massey JM. Myasthenia gravis. Orphanet J Rare Dis. 2007;2:44.
Lee I, Kaminkski H, McPherson T, et al. Gender differences in prednisone adverse effects Survey result from the MG registry. Neurol Neuroimmunol Neuroinflamm. 2018; 5:e507.
Werneck LC, Scola RH, Germiniani FM, Comerlato EA, Cunha FM. Myasthenic crisis: report of 24 cases. Arq Neuropsiquiatr. 2002;60(3-A):519-526.
Andersen L, Jakobsson A, Revsbech, K, Vissing J. Causes of symptom dissatisfaction in patients with generalized myasthenia gravis. J Neurol. Published online November 21, 2021. doi:10.1007/s00415-021-10902-1
Baggi F, Andreetta F, Maggi L, et al. Complete stable remission and autoantibody specificity in myasthenia gravis. Neurology. 2013;80(2):188-195.
Imai T, Utsugisawa K, Murai H, et al. Oral corticosteroid dosing regimen and long-term prognosis in generalised myasthenia gravis: a multicentre cross-sectional study in Japan. J Neurol Neurosurg Psychiatry. 2018;89(5):513-517.
Kaminski HJ, Kusner LL. Myasthenia Gravis and Related Disorders. 3rd ed. Humana Press. 2018.
Blum S, Lee D, Gillis D, McEniery DF, Reddel S, McCombe P. Clinical features and impact of myasthenia gravis disease in Australian patients. J Clin Neurosci. 2015;22(7):1164-1169.
Anil R, Kumar A, Alaparthi S, et al. Exploring outcomes and characteristics of myasthenia gravis: rationale, aims and design of registry–the EXPLORE-MG registry. J Neurol Sci. 2020;414:116830.
Lindstrom J, Seybold M, Lennon V, et al. Antibody to acetylcholine receptor in myasthenia gravis. Neurology. 1976;26:1054-1059.
Vincent A, Newson-Davis J. Acetylcholine receptor antibody as a diagnostic test for myasthenia gravis: results in 153 validated cases and 2967 diagnostic assays. J Neurol Neurosurg Psychiatry. 1985;48:1246-1252.
Burden SJ, Yumoto N, Zhang W. The role of MuSK in synapse formation and neuromuscular disease. Cold Spring Harb Perspect Biol. 2013;5(5):a009167.
Nagane Y, Murai H, Imai T, et al. Social disadvantages associated with myasthenia gravis and its treatment: a multicentre cross-sectional study. BMJ Open. 2017;7(2):e013278.
Nowak RJ. Myasthenia gravis: challenges and burdens of disease. Neurology Reviews. March 2018. Accessed April 2022. https://www.neurologyreviews-digital.com/neurologyreviews/nord_supplement_0318/MobilePagedArticle.action articleId=1361082#articleId1361082
The CIE. The cost to patients and the community of Myasthenia Gravis. Centre for International Economics; November 2013. Accessed May 1, 2022. http://www.thecie.com.au/wp-content/uploads/2014/06/Final-report_Economic-Impact-of-Myasthenia-Gravis-08112013.pdf
Twork S, Wiesmeth S, Klewer J, Pöhlau D, Kugler J. Quality of life and life circumstances in German myasthenia gravis patients. Health Qual Life Outcomes. 2010;8:129.
Ruiter A, Verschuuren J, Tannemaat M. Fatigue in patients with myasthenia gravis. A systematic review of the literature. Neuromuscular Disorders. 2020;30(8):631-639.
Stewart SB, Roberston KR, Johnson KM, Howard JF Jr. The prevalence of depression in myasthenia gravis. J Clin Neuromusc Dis. 2007;8(3):111-115.
Harris L, Aban IB, Xin H, Cutter G. Employment in refractory myasthenia gravis: A Myasthenia Gravis Foundation of America Registry analysis. Muscle Nerve. 2019;60(6):700-706.
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Gilhus NE. Myasthenia gravis. N Engl J Med. 2016;375(26):2570-2581.
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DISCOVER WHY UNCONTROLLED gMG NEVER RESTS

SEE SOME HALLMARKS OF UNCONTROLLEDDISEASE IN PATIENTS

WHAT CAUSES gMG?

HOW CAN YOU IDENTIFY UNCONTROLLED gMG?

IS gMG UNCONTROLLED IN THESE PATIENTS?

RESOURCES

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DISCOVER WHY
UNCONTROLLED gMG
NEVER RESTS

SEE SOME HALLMARKS OF UNCONTROLLED
DISEASE IN PATIENTS